Table 3.

Cox proportional hazard models for DRFS and BCSS.

	DRFS				BCSS
Variables	Univariate models HR (95% CI)	P	Multivariable model HR (95% CI)	P	Univariate models HR (95% CI)	P	Multivariable model HR (95% CI)	P
Age	0.98 (0.94–1.01)	0.13	0.98 (0.95–1.02)	0.36	0.99 (0.96–1.02)	0.43	1.00 (0.96–1.04)	0.98
Tumor size		0.003		0.30		0.002		0.97
pT2 vs. pT1	2.44 (1.46–4.09)	0.001	1.41 (0.77–2.58)	0.27	2.47 (1.46–4.17)	0.001	1.08 (0.56–2.07)	0.83
pT3 vs. pT1	1.35 (0.18–10.00)	0.77	0.41 (0.05–3.43)	0.41	3.05 (0.72–12.97)	0.13	0.98 (0.19–5.19)	0.98
Nodal status		<0.0001		<0.0001		<0.0001		<0.0001
1–3 vs. 0 nodes	1.64 (0.85–3.17)	0.14	1.17 (0.56–2.43)	0.68	1.61 (0.82–3.15)	0.16	1.25 (0.58–2.70)	0.57
4–10 vs. 0 nodes	6.24 (3.25–11.95)	<0.0001	5.31 (2.59–10.87)	<0.0001	5.84 (2.97–11.48)	<0.0001	4.48 (2.00–10.00)	0.0003
>10 vs. 0 nodes	7.81 (3.58–17.04)	<0.0001	11.16 (4.21–29.60)	<0.0001	9.45 (4.55–19.62)	<0.0001	10.27 (3.63–29.08)	<0.0001
Tumor grade		0.15		0.50		0.03		0.64
G2 vs. G1	1.84 (0.82–4.13)	0.14	1.71 (0.70–4.16)	0.24	1.59 (0.70–3.59)	0.27	1.38 (0.56–3.41)	0.49
G3 vs. G1	2.39 (0.99–5.72)	0.05	1.56 (0.54–4.50)	0.42	2.76 (1.18–6.45)	0.02	1.67 (0.58–4.82)	0.34
HER2	1.86 (0.91–3.82)	0.09	1.93 (0.92–4.07)	0.08	2.59 (1.32–5.09)	0.006	2.88 (1.39–5.98)	0.004
ESR1 amp/gain	0.53 (0.31–0.89)	0.02	0.48 (0.26–0.91)	0.02	0.56 (0.34–0.95)	0.03	0.47 (0.27–0.80)	0.01