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Hippo pathway and its targeted inhibitors. Mst1/2 kinase and SAV1 form a complex that phosphorylates and activates LATs1/2; Lats1/2 kinase in turn phosphorylates and inhibits the transcription coactivators YAP and TAZ; and after dephosphorylation, YAP/TAZ is transferred to the cell nucleus and activates transcription factors such as TEAD1-4, thereby inducing and promoting cell proliferation, and inhibiting apoptosis. The red text represents the targeted inhibitor for this target.
