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. 2022 Aug 21;12(14):6160–6178. doi: 10.7150/thno.70814

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Prognostic implications of altered metabolic genes. (A) Twenty-seven metabolic genes with indicated genomic alterations could serve as independent prognostic factors for outcome in ESCC. (B) Validated prognostic markers in the independent Proteomics Cohort. (C) Kaplan-Meier survival curve for the mutated metabolic gene panel (ADCY2, CACNA1D, GRIK2, KCNMA1, KCNQ3). (D) The mutated metabolic gene panel was associated with the stage (top) and lymph node metastasis (bottom). (E) Multivariate Cox regression survival analysis of the mutated metabolic gene panel. (F) Kaplan-Meier survival curve for the CNA-loss affected metabolic gene panel (SLN, ACAT1, and GUCY1A2). (G) Multivariate Cox regression survival analysis of the CNA-loss affected metabolic gene panel.