Table 2.
Representative CAR-T cell clinical trials for solid tumors.
| NCT Number | Phase | Status | Tumor types | Interventions | Study result |
|---|---|---|---|---|---|
| NCT03851146 | Ⅰ | Completed | Advanced Cancer | LeY CAR-T cells | - |
| NCT03706326 | Ⅰ | Ⅱ | Unknown status | Advanced Esophageal Cancer | Anti-MUC1 CAR-T cells | - |
| NCT03874897 | Ⅰ | Recruiting | Advanced Solid Tumor | CAR-CLDN18.2 T-Cells | - |
| NCT02862028 | Ⅰ | Ⅱ | Unknown status | Advanced Solid Tumor | HerinCAR-PD1 cells | - |
| NCT05287165 | Ⅰ | Recruiting | Digestive System Neoplasms | Pancreatic Cancer | Colorectal Cancer | IM96 CAR-T cells | - |
| NCT05275062 | Ⅰ | Recruiting | Gastric Cancer | Esophagogastric Cancer | Pancreatic Cancer | IM92 CAR-T cells | - |
| NCT03356795 | Ⅰ | Ⅱ | Unknown status | Cervical Cancer | Cervical cancer-specific CAR-T cells | - |
| NCT05089266 | Ⅰ | Not yet recruiting | Colorectal Cancer | αPD1-MSLN-CAR-T cells | - |
| NCT05415475 | Ⅰ | Recruiting | Colorectal Cancer | Esophageal Cancer | Stomach Cancer | Pancreatic Cancer | CEA CAR-T cells | - |
| NCT04503980 | Ⅰ | Recruiting | Colorectal Cancer | Ovarian Cancer | αPD1-MSLN-CAR T cells | - |
| NCT05341492 | Ⅰ | Recruiting | Lung Cancer | Breast Cancer | EGFR/B7H3 CAR-T cells | - |
| NCT04581473 | Ⅰ | Ⅱ | Recruiting | Gastric Adenocarcinoma | Pancreatic Cancer | Gastroesophageal Adenocarcinoma | CT041 autologous CAR-T cells | - |
| NCT05131763 | Ⅰ | Recruiting | Hepatocellular Carcinoma | Glioblastoma | Medulloblastoma | Colon Cancer | NKG2D-based CAR-T cells | - |
| NCT02932956 | Ⅰ | Active, not recruiting | Liver Cancer | Glypican 3-specific CAR-T cells | - |
| NCT04489862 | Ⅰ | Recruiting | Non-small-cell Lung Cancer | Mesothelioma | αPD1-MSLN-CAR-T cells | - |
| NCT04864821 | Ⅰ | Not yet recruiting | Osteosarcoma | Neuroblastoma | Gastric Cancer | Lung Cancer | Targeting CD276 CAR-T cells | - |
| NCT04981691 | Ⅰ | Recruiting | Refractory Malignant Solid Neoplasm | anti-MESO CAR-T cells | - |
| NCT03356782 | Ⅰ | Ⅱ | Recruiting | Sarcoma | Osteoid Sarcoma | Ewing Sarcoma | Sarcoma-specific CAR-T cells | - |
| NCT02107963 | Ⅰ | Completed | Sarcoma | Osteosarcoma | Neuroblastoma | Melanoma | Anti-GD2-CAR engineered T cells | - |
| NCT03545815 | Ⅰ | Recruiting | Solid Tumor | anti-mesothelin CAR-T cells | - |
| NCT05437315 | Ⅰ | Ⅱ | Recruiting | Solid Tumor | bi-4SCAR GD2/PSMA T cells | - |
| NCT05382377 | Ⅰ | Recruiting | Solid Tumor | NKG2D CAR-T cells | - |
| NCT05373147 | Ⅰ | Recruiting | Solid Tumor | αPD1-MSLN-CAR-T cells | - |
| NCT04976218 | Ⅰ | Recruiting | Solid Tumor | EGFR Overexpression | TGFβR-KO CAR-EGFR T Cells | - |
| NCT04467853 | Ⅰ | Recruiting | Solid Tumors | LCAR-C18S cells | - |
-: No Results Available