Figure 6. Sox6 role in basal cell proliferation and survival during homeostasis and acute UV response.

• A
  Schematic of Sox6 epithelial knockout (iKO) and BrdU pulse‐chase experiment.
• B–G
  (B, D, and F) Images of tail skin immune‐stained for markers indicated and (C, E, and G) corresponding box plots.
• H
  Sox6 role in acute UV‐response was assessed in back skin to avoid compounding effects from the nucleus‐retaining cornified envelope in tail scales.
• I–N
  (I, K, and M) Images of skin immune‐stained for markers indicated and (J, L, and N) corresponding box plots.
• O
  Model depicting the role of Sox6 in IFE homeostasis and acute UV response.

Data information: In box plots, central band is the mean value, and the top indicates 25^th percentile while the bottom indicates 75^th percentile. Whiskers indicate minimum and maximum values in the data, with dots indicating potential outliers. Linear mixed model statistical test was used with data from 18 images from three biological replicates.