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. 2022 Sep 14;9(2):e002043. doi: 10.1136/openhrt-2022-002043

Table 2.

Predictors of poor TTR

Characteristics Coefficient (95% CI) P value
CKD stages
 eGFR ≥90 Reference
 eGFR 60–89 3.9 (2.2 to 5.6) <0.001
 eGFR 30–59 3.0 (1.1 to 5.0) 0.002
 eGFR 15–29 −0.9 (−4.0 to 2.2) 0.58
 eGFR <15/dialysis −5.5 (−11.0 to 0.1) 0.05
Age (/10 years) 0.4 (−0.1 to 1.0) 0.12
Sex, female −0.7 (−1.6 to 0.2) 0.14
Hypertension 0.2 (−0.8 to 1.1) 0.70
Diabetes mellitus −2.1 (−3.4 to −0.9) <0.001
Prior stroke/TIA/systemic embolism 0.6 (−0.7 to 1.9) 0.34
Prior MI 0.7 (−1.3 to 2.6) 0.50
Prior PCI or CABG 0.2 (−1.5 to 1.9) 0.82
Heart failure −3.5 (−4.9 to −2.2) <0.001
Peripheral vascular disease −1.8 (−3.9 to 0.3) 0.10
COPD −6.3 (−8.2 to −4.5) <0.001
Cancer (within 3 years) −0.2 (−2.1 to 1.8) 0.86
Prior major bleeding −1.6 (−3.4 to 0.2) 0.08
Acetylsalicylic acid −1.5 (−2.6 to −0.4) 0.01
P2Y12 inhibitor 0.5 (−2.5 to 3.5) 0.74

CABG, coronary artery bypass grafting; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; MI, myocardial infarction; PCI, percutaneous coronary intervention; TIA, transient ischaemic attack; TTR, time in therapeutic range.