Table 3.
Predictors of worsening renal function (≥20% decline in eGFR) over time
| Characteristics | OR (95% CI) | P value |
| CKD stages | ||
| eGFR ≥90 | Reference | |
| eGFR 60–89 | 1.13 (0.79 to 1.61) | 0.51 |
| eGFR 30–59 | 1.05 (0.71 to 1.55) | 0.82 |
| eGFR 15–29 | 1.09 (0.61 to 1.97) | 0.77 |
| eGFR <15/dialysis | 1.25 (0.39 to 3.97) | 0.71 |
| Age (/10 years) | 1.49 (1.35 to 1.65) | <0.001 |
| Sex, female | 1.29 (1.10 to 1.52) | 0.002 |
| Hypertension | 1.17 (0.98 to 1.39) | 0.09 |
| Diabetes mellitus | 1.55 (1.27 to 1.90) | <0.001 |
| Prior stroke/TIA/systemic embolism | 0.75 (0.60 to 0.95) | 0.02 |
| Prior MI | 1.01 (0.73 to 1.40) | 0.93 |
| Prior PCI or CABG | 1.13 (0.85 to 1.49) | 0.41 |
| Heart failure | 1.91 (1.53 to 2.39) | <0.001 |
| Peripheral vascular disease | 1.31 (0.93 to 1.83) | 0.12 |
| COPD | 1.34 (0.99 to 1.81) | 0.06 |
| Cancer (within 3 years) | 0.81 (0.57 to 1.16) | 0.26 |
| Prior major bleeding | 1.21 (0.89 to 1.63) | 0.23 |
CABG, coronary artery bypass grafting; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; MI, myocardial infarction; PCI, percutaneous coronary intervention; TIA, transient ischaemic attack.