Table 4. Antiproliferative Activity of Synthesized 1,2,3-Triazole (18a–n) against an NCI Panel of 60 Human Cancer Cell Lines.
| PANELNME | comp no. | 16c | 18a | 18b | 18c | 18d | 18e | 18f | 18g | 18h | 18i | 18j | 18k | 18l | 18m | 18n |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| leukemia | CCRF-CEM | 70.56 | 59.43 | 92.94 | 76.55 | 40.10 | 116.05 | 84.49 | 81.06 | 85.57 | 36.52 | 97.09 | 83.96 | 97.30 | 58.35 | 61.14 |
| HL-60(TB) | 76.37 | 93.01 | 87.80 | 83.86 | 41.06 | 95.54 | 83.95 | 110.2 | 100.27 | 47.68 | 96.30 | 89.26 | 91.54 | 70.85 | 88.43 | |
| K-562 | 89.43 | 79.40 | 53.52 | 60.82 | 44.62 | 81.37 | 51.89 | 44.88 | 83.08 | 51.53 | 59.00 | 72.74 | 81.62 | 47.60 | 66.32 | |
| MOLT-4 | 83.43 | 54.59 | 71.73 | 47.68 | 16.29 | 84.05 | 68.65 | 64.23 | 80.63 | 20.66 | 84.80 | 67.45 | 74.84 | 14.78 | 69.97 | |
| RPMI-8226 | 84.37 | 37.90 | 75.30 | 56.33 | 47.56 | 90.71 | 77.63 | 73.14 | 73.29 | 39.91 | 89.81 | 75.33 | 81.80 | 58.26 | 69.27 | |
| SR | 90.57 | 62.33 | 65.77 | 61.39 | 48.53 | 79.78 | 27.12 | 39.18 | 81.95 | 45.13 | 41.51 | 68.94 | 73.39 | 24.73 | 63.80 | |
| non-small cell lung cancer | A549/ATCC | 96.36 | 94.07 | 57.07 | 81.77 | 64.07 | 59.42 | 46.49 | 85.48 | 56.83 | 65.65 | 42.61 | 76.78 | 80.64 | 48.20 | 78.59 |
| EKVX | 86.35 | 74.29 | 75.34 | 51.21 | 54.00 | 81.06 | 77.24 | 75.25 | 69.05 | 58.81 | 92.14 | 65.19 | 78.32 | 81.03 | 79.03 | |
| HOP-62 | 85.81 | 120.28 | 61.55 | 89.31 | 79.25 | 11.33 | 95.67 | 103.84 | 82.74 | 78.10 | 88.76 | 67.99 | 46.72 | 88.63 | 65.10 | |
| HOP-92 | 83.48 | 103.88 | 53.02 | 71.92 | 79.43 | –3.27 | 51.60 | 86.49 | 76.24 | 57.55 | 86.10 | 55.58 | 4.63 | 65.16 | 45.94 | |
| NCI-H226 | 100.60 | 79.51 | 63.78 | 54.16 | 59.73 | 66.35 | 50.55 | 80.08 | 73.48 | 56.87 | 72.34 | 51.40 | 73.35 | 54.94 | 70.24 | |
| NCI-H23 | 94.13 | 91.88 | 64.87 | 72.88 | 64.51 | 56.64 | 68.51 | 45.49 | 66.55 | 62.45 | 79.35 | 74.89 | 68.25 | 64.54 | 60.06 | |
| NCI-H322M | 91.13 | 106.92 | 83.48 | 104.66 | 91.28 | 95.25 | 82.51 | 92.29 | 103.37 | 94.44 | 90.10 | 105.20 | 92.68 | 94.96 | 99.60 | |
| NCI-H460 | 103.61 | 97.03 | 65.04 | 88.73 | 78.43 | 75.06 | 45.51 | 78.17 | 62.92 | 84.19 | 14.61 | 79.49 | 89.03 | 45.78 | 74.17 | |
| NCI-H522 | 86.86 | 85.53 | 62.93 | 67.33 | 51.40 | 55.44 | 61.51 | 58.92 | 80.13 | 61.88 | 83.09 | 66.40 | 57.14 | 63.51 | 41.63 | |
| colon cancer | COLO 205 | 105.96 | 99.03 | 91.10 | 102.61 | 71.71 | 104.99 | 53.63 | 121.73 | 94.43 | 78.01 | 74.25 | 97.16 | 111.74 | 95.57 | 112.90 |
| HCC-2998 | 108.39 | 93.30 | 75.87 | 94.66 | 91.88 | 92.47 | 93.52 | 107.31 | 91.41 | 106.48 | 111.05 | 94.86 | 100.56 | 89.49 | 95.80 | |
| HCT-116 | 94.11 | 96.71 | 38.23 | 72.22 | 49.66 | 53.13 | 29.82 | 32.09 | 18.65 | 49.09 | 12.49 | 47.86 | 60.15 | 29.43 | 41.92 | |
| HCT-15 | 100.88 | 88.04 | 65.29 | 81.43 | 53.84 | 79.57 | 29.35 | 71.79 | 80.93 | 62.42 | 56.79 | 91.65 | 82.81 | 66.16 | 82.35 | |
| HT29 | 103.79 | 99.48 | 79.57 | 97.34 | 76.66 | 82.28 | 78.27 | 108.14 | 100.11 | 22.55 | 96.61 | 102.98 | 97.40 | 77.55 | 94.43 | |
| KM12 | 100.37 | 96.04 | 87.72 | 94.27 | 62.97 | 93.06 | 82.66 | 86.78 | 91.32 | 63.85 | 84.99 | 96.37 | 99.29 | 71.66 | 94.59 | |
| SW-620 | 98.70 | 76.75 | 97.41 | 80.24 | 89.26 | 29.90 | 86.83 | 80.92 | 92.93 | 38.71 | 101.33 | 92.72 | 71.03 | 91.70 | ||
| CNS cancer | SF-268 | 77.04 | 92.33 | 95.38 | 85.96 | 82.41 | 52.34 | 58.39 | 88.77 | 73.15 | 78.08 | 83.86 | 69.92 | 58.88 | 71.57 | 71.71 |
| SF-295 | 103.18 | 88.16 | 55.55 | 66.84 | 56.38 | 41.76 | 80.45 | 70.15 | 96.45 | 60.45 | 72.87 | 64.41 | 45.20 | 54.05 | 63.24 | |
| SF-539 | 93.56 | 96.00 | 67.72 | 73.07 | 75.23 | 66.88 | 5.30 | 43.12 | 69.79 | 66.99 | 16.35 | 68.43 | 44.60 | 59.74 | 51.16 | |
| SNB-19 | 95.32 | 74.44 | 78.63 | 67.87 | 61.27 | 49.98 | 81.31 | 84.82 | 73.39 | 66.43 | 97.17 | 53.11 | 55.68 | 83.59 | 57.66 | |
| SNB-75 | 56.78 | 41.60 | 60.00 | 7.99 | 47.20 | 78.02 | 56.57 | 65.15 | 10.58 | 54.57 | 47.32 | |||||
| U251 | 98.73 | 93.80 | 57.71 | 102.61 | 80.61 | 54.40 | 48.23 | 82.82 | 40.06 | 62.83 | 50.97 | 65.37 | 61.60 | 83.86 | 63.36 | |
| melanoma | LOX IMVI | 92.96 | 92.33 | 59.71 | 75.06 | 56.37 | 80.73 | 50.61 | 62.72 | 71.40 | 62.00 | 80.73 | 81.38 | 76.70 | 72.59 | 74.03 |
| MALME-3M | 90.29 | 88.78 | 68.35 | 87.23 | 68.22 | 79.26 | 77.44 | 76.19 | 71.40 | 70.30 | 80.81 | 96.02 | 78.28 | 75.36 | 85.41 | |
| M14 | 95.93 | 85.67 | 90.80 | 93.39 | 55.87 | 102.02 | 89.03 | 88.83 | 82.48 | 65.91 | 92.12 | 102.20 | 94.79 | 88.23 | 97.23 | |
| MDA-MB-435 | 102.18 | 97.17 | 84.94 | 93.75 | 66.50 | 98.16 | 91.28 | 88.25 | 99.53 | 74.94 | 74.88 | 103.84 | 100.50 | 81.26 | 98.30 | |
| SK-MEL-2 | 101.97 | 91.22 | 83.62 | 95.46 | 53.30 | 71.68 | 93.67 | 64.50 | 95.86 | 66.32 | 110.78 | 84.61 | 78.55 | 79.97 | 78.04 | |
| SK-MEL-28 | 106.36 | 99.70 | 86.95 | 76.60 | 69.78 | 96.28 | 89.28 | 87.77 | 98.47 | 85.31 | 91.55 | 89.56 | 94.93 | 85.39 | 96.54 | |
| SK-MEL-5 | 97.72 | 77.37 | 62.77 | 89.51 | 5.29 | 60.43 | 71.91 | 35.89 | 86.20 | 16.33 | 78.75 | 65.24 | 70.80 | 31.05 | 55.65 | |
| UACC-257 | 112.93 | 101.28 | 85.53 | 72.07 | 60.33 | 91.96 | 91.04 | 69.39 | 92.03 | 71.22 | 103.84 | 69.92 | 94.00 | 68.74 | 86.34 | |
| UACC-62 | 81.15 | 64.23 | 65.67 | 108.08 | 39.56 | 65.59 | 69.35 | 53.53 | 65.91 | 48.01 | 72.06 | 64.41 | 69.54 | 56.65 | 65.15 | |
| ovarian cancer | IGROV1 | 89.12 | 88.78 | 80.15 | 95.28 | 87.05 | 72.31 | 83.14 | 78.76 | 106.74 | 78.93 | 102.20 | 97.38 | 81.86 | 81.49 | 89.93 |
| OVCAR-3 | 94.85 | 116.94 | 82.26 | 70.95 | 83.57 | 101.33 | 60.12 | 107.92 | 98.44 | 80.34 | 102.85 | 107.56 | 105.46 | 94.05 | 104.69 | |
| OVCAR-4 | 78.72 | 95.26 | 52.67 | 106.44 | 33.26 | 49.69 | 53.41 | 63.75 | 63.65 | 45.26 | 45.13 | 73.07 | 71.43 | 55.29 | 49.55 | |
| OVCAR-5 | 93.28 | 69.23 | 80.72 | 72.31 | 93.08 | 91.71 | 86.36 | 101.94 | 98.00 | 95.61 | 97.48 | 101.77 | 94.92 | 97.97 | 105.21 | |
| OVCAR-8 | 99.92 | 107.77 | 49.14 | 57.30 | 49.81 | 29.30 | 46.30 | 63.55 | 23.70 | 48.57 | 28.11 | 52.29 | 66.47 | 59.99 | 47.52 | |
| NCI/ADR-RES | 94.46 | 81.94 | 47.96 | 99.18 | 24.02 | 32.86 | 36.55 | 17.58 | 3.67 | 36.03 | 44.05 | 45.40 | 54.77 | 14.02 | 52.06 | |
| SK-OV-3 | 97.77 | 47.99 | 72.13 | 75.06 | 82.97 | 26.10 | 99.00 | 80.08 | 95.87 | 68.44 | 88.99 | 85.05 | 43.56 | 82.43 | 64.02 | |
| renal cancer | 786-0 | 113.25 | 84.28 | 92.28 | 87.70 | 38.94 | 80.43 | 97.04 | 71.40 | 83.46 | 92.98 | 68.16 | 43.58 | 96.24 | 68.65 | |
| A498 | 103.70 | 92.16 | 98.87 | 141.89 | 106.80 | 58.98 | 79.95 | 92.59 | 91.34 | 107.83 | 90.96 | 136.18 | 103.28 | 92.30 | 104.93 | |
| ACHN | 96.18 | 110.84 | 44.83 | 80.22 | 67.59 | 61.09 | 71.52 | 72.71 | 111.72 | 80.79 | 77.61 | 69.02 | 65.32 | 72.75 | 56.39 | |
| CAKI-1 | 81.89 | 93.22 | 45.87 | 87.58 | 46.28 | 31.84 | 64.04 | 72.08 | 69.51 | 48.65 | 73.63 | 81.82 | 55.08 | 62.58 | 28.75 | |
| RXF 393 | 104.03 | 90.76 | 56.13 | 79.87 | 72.64 | 14.13 | 74.78 | 90.59 | 83.02 | 55.93 | 88.27 | 52.33 | 38.41 | 49.41 | 61.80 | |
| SN12C | 82.18 | 98.10 | 67.70 | 79.39 | 69.58 | 64.79 | 38.19 | 70.68 | 96.63 | 73.66 | 27.14 | 80.79 | 76.12 | 77.75 | 71.63 | |
| TK-10 | 120.42 | 88.46 | 95.63 | 99.80 | 93.11 | 68.70 | 90.74 | 104.96 | 72.43 | 113.60 | 101.93 | 91.77 | 95.83 | 105.47 | 108.92 | |
| UO-31 | 60.69 | 62.50 | 30.26 | 60.54 | 60.75 | 42.13 | 36.50 | 75.65 | 71.89 | 50.93 | 62.92 | |||||
| prostate cancer | PC-3 | 83.21 | 83.14 | 80.17 | 76.26 | 49.41 | 85.05 | 65.91 | 85.51 | 75.72 | 48.11 | 82.47 | 80.20 | 87.92 | 68.16 | 81.39 |
| DU-145 | 102.58 | 92.07 | 82.81 | 86.56 | 90.12 | 90.48 | 76.78 | 86.40 | 84.49 | 77.90 | 100.88 | 93.09 | 101.70 | 73.70 | 92.71 | |
| breast cancer | MCF7 | 97.19 | 80.61 | 51.57 | 63.32 | 40.61 | 67.54 | 49.58 | 63.96 | 74.54 | 50.45 | 56.77 | 77.07 | 66.90 | 42.30 | 60.21 |
| MDA-MB-231/ATCC | 79.57 | 59.59 | 72.60 | 59.66 | 75.74 | 76.76 | 71.94 | 87.20 | 66.80 | 81.38 | 80.58 | |||||
| HS 578T | 100.24 | 71.37 | 52.51 | 80.95 | 48.38 | 57.02 | 81.99 | 68.23 | 73.67 | 94.33 | 33.70 | 39.51 | 76.00 | 73.79 | ||
| BT-549 | 95.55 | 83.27 | 87.40 | 66.42 | 28.16 | 83.67 | 71.72 | 72.57 | 77.08 | 24.05 | 92.35 | 79.69 | 70.98 | 58.51 | 93.63 | |
| T-47D | 89.01 | 66.00 | 52.46 | 58.60 | 9.14 | 60.21 | 33.60 | 46.14 | 58.91 | 14.63 | 32.42 | 67.90 | 60.60 | 35.97 | 49.34 | |
| MDA-MB-468 | 99.02 | 66.15 | 41.27 | 43.43 | 28.48 | 50.44 | 54.99 | 41.44 | 56.62 | 31.66 | 64.90 | 64.96 | 57.69 | 30.23 | 46.73 |