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. 2022 Sep 14;10:137. doi: 10.1186/s40478-022-01442-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Age distribution and outcome of PFA_EPN, EZHIP-overexpressing and H3K27M-mutant of our cohort (n = 7) and cases from the literature with available methylation data (n = 2, cases #10 and #11). Median age for EPN_PFA, H3K27M-mutant of 6 years (1.4–12) versus 2.4 years for EPN_PFA, EZHIP-overexpressing (0.1–22.5). Statistical significance was calculated with Mann–Whitney test (median, *p value 0.0168, n = 98) (a). Kaplan–Meier survival estimates of EFS and OS: no significant difference between EPN_PFA, EZHIP-overexpressing (red, n = 89, median EFS 28 months, median OS 123 months) and H3K27M-mutant (orange, n = 9, median EFS 79 months, median OS not reached), log rank test, p value 0.67 and 0.41 respectively (b, c). DMG: diffuse midline gliomas; EPN: ependymomas; EFS: event-free survival; OS: overall survival; PF: posterior fossa