Fig. 3.

Systematic computational framework for studies in the field of AD brain imaging biomarker genomics. The top panel indicates the analytical steps involved in imaging: image preprocessing, identification of regions of interest, feature extraction, feature selection, and model building and evaluation. The middle panel represents genomics procedures: genetic preprocessing, feature extraction and dimension reduction, model building, and statistical analysis. The bottom panel indicates integrated analysis methods in studies of imaging biomarker genomics, including association analysis, classification and prediction