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The process of hexosamine biosynthetic pathway (HBP) and O-GlcNAcylation. HBP integrates multiple metabolic pathways and the end product UDP-GlcNAc acts as a sugar donor for protein O-GlcNAcylation. HK hexokinase, GPI glucose-6-phosphate isomerase, GFAT glutamine:fructose-6-phosphate amidotransferase, GNAT glucosamine 6-phosphate N-acetyltransferase, PGM phosphoglucomutase, UAP UDP-N-acetylglucosamine pyrophosphorylase, TCA tricarboxylic acid cycle, OXPHOS oxidative phosphorylation
