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. 2022 Sep 15;17:61. doi: 10.1186/s13012-022-01233-4
Power based on three-arm design
Key Assumptions 13 clusters per arm (alpha=0.05/2=0.025);
m = 79; ICC = 0.012; CV = 0.47
Primary Outcome Comparison Expected Effect Size Power

Combined Interventions (PD+CD) vs.

Control Arm

30% (PD+CD) – 8% (Control) =

22 percentage points

99.8%

Combined Interventions (PD+CD) vs.

Client Directed Intervention (CD)

30% (PD+CD) – 14.6% (CD) =

15.4 percentage points

86.0%

Notes: m, expected median cluster size by the end of the study; ICC, intraclass correlation coefficient; CV, coefficient of variation of cluster size