TABLE 1.
Shared pleiotropic loci between AD and glaucoma.
| # | SNP | Genomic position | Closest gene | ccFDR |
| 1 | rs2856661 | 11:47374998 | SPI1, MYBPC3 | 2.59E−05 |
| 2 | rs11039199 | 11:47379212 | SPI1 | 9.99E−06 |
| 3 | rs7105851 | 11:47383275 | SPI1 | 1.94E−05 |
| 4 | rs11039203 | 11:47384597 | SPI1 | 2.00E−05 |
| 5 | rs67116452 | 11:47385194 | SPI1 | 1.41E−05 |
| 6 | rs10838698 | 11:47385923 | SPI1 | 3.81E−05 |
| 7 | rs10838699 | 11:47386073 | SPI1 | 2.46E−05 |
| 8 | rs935914 | 11:47387599 | SPI1 | 1.45E−05 |
| 9 | rs35996350 | 11:47389223 | SPI1 | 2.25E−05 |
| 10 | rs4752827 | 11:47389676 | SPI1 | 3.40E−05 |
| 11 | rs4752987 | 11:47390692 | SPI1 | 1.16E−05 |
| 12 | rs10769258 | 11:47391039 | SPI1 | 1.29E−05 |
| 13 | rs11039212 | 11:47393303 | SPI1 | 2.12E−05 |
| 14 | rs7940536 | 11:47395240 | SPI1 | 2.83E−05 |
| 15 | rs56030824 | 11:47397353 | SPI1 | 1.17E−05 |
| 16 | rs55677087 | 11:47397714 | SPI1 | 1.38E−05 |
| 17 | rs12146565 | 11:47398963 | SPI1 | 2.26E−05 |
| 18 | rs11601173 | 11:47401058 | SPI1 | 1.30E−05 |
| 19 | rs11607981 | 11:47401060 | SPI1 | 1.37E−05 |
| 20 | rs7111957 | 11:47409212 | SPI1 | 1.57E−05 |
| 21 | rs4752990 | 11:47410393 | SPI1 | 1.29E−05 |
| 22 | rs4752993 | 11:47410951 | SPI1 | 1.25E−05 |
| 23 | rs4752994 | 11:47411065 | SPI1 | 5.90E−05 |
| 24 | rs10769262 | 11:47411581 | SPI1 | 3.61E−05 |
| 25 | rs12803525 | 11:47413475 | SPI1 | 1.02E−05 |
| 26 | rs12802273 | 11:47418306 | SPI1 | 1.83E−05 |
| 27 | rs58965622 | 11:47418465 | SPI1 | 9.86E−06 |
| 28 | rs7924485 | 11:47419129 | SPI1 | 1.38E−05 |
| 29 | rs1317164 | 11:47419757 | MTCH2 | 9.46E−06 |
| 30 | rs4752832 | 11:47423553 | MTCH2 | 1.21E−05 |
| 31 | rs11039219 | 11:47424400 | MTCH2 | 1.12E−05 |
| 32 | rs755554 | 11:47432034 | SLC39A13 | 1.38E−05 |
| 33 | rs11600581 | 11:47448497 | PSMC3 | 1.07E−05 |
| 34 | rs2868459 | 11:47454972 | MTCH2 | 1.32E−05 |
| 35 | rs7106956 | 11:47458765 | MTCH2 | 1.96E−05 |
| 36 | rs35705029 | 11:47459963 | RAPSN | 9.83E−06 |
| 37 | rs4752845 | 11:47539697 | CELF1 | 9.17E−06 |
| 38 | rs34958982 | 11:47547046 | CELF1 | 1.73E−05 |
| 39 | rs66749409 | 11:47568074 | CELF1 | 1.94E−05 |
| 40 | rs12798346 | 11:47583121 | CELF1 | 2.08E−05 |
| 41 | rs56400411 | 11:47586376 | CELF1, PTPMT1 | 1.61E−05 |
| 42 | rs7945473 | 11:47589707 | PTPMT1 | 1.33E−05 |
| 43 | rs2030166 | 11:47602729 | NDUFS3 | 1.85E−05 |
| 44 | rs11605348 | 11:47606483 | FAM180B, NDUFS3 | 2.65E−05 |
| 45 | rs4752856 | 11:47648042 | MTCH2 | 1.53E−05 |
| 46 | rs4752857 | 11:47655752 | MTCH2 | 2.12E−05 |
| 47 | rs11039327 | 11:47674084 | MTCH2 | 8.99E−06 |
| 48 | rs11604825 | 11:47725306 | AGBL2 | 1.55E−05 |
| 49 | rs11602395 | 11:47726977 | AGBL2 | 8.76E−06 |
Forty-nine pleiotropic loci reach statistically significant ccFDR (<0.01) and are shared by AD and glaucoma phenotypes.