Figure 1.

Cumulative lifetime and 10-year absolute risk of developing breast cancer among African Americans according to percentiles of the polygenic risk scores (PRSs). Cumulative lifetime absolute risk of developing (A) overall breast cancer, (B) estrogen receptor (ER)–positive breast cancer, and (C) ER-negative breast cancer. 10-year absolute risk of developing (D) overall breast cancer, (E) ER-positive breast cancer, and (F) ER-negative breast cancer. The pink dotted line in (d) demonstrates the 2% risk threshold that could be used to recommend screening age.