Table 2.

DDSs for multi-components from Danshen.

Drug delivery systems		Materials	Drugs	Advantages	References
Tablets	Multiple release drug bilayer tablets	MCC, PVPP, L-HPC, HPMC, CP934p, and lactose	Hydrophilic extract from Danshen, and Lipophilic extract from Danshen	Characteristics of quick release and slow release in vitro	(Peng et al., 2010)
	Osmotic pump tablets	PEO, PVPP, PVP, CA, DBP, PEG 400, and NaCl	Hydrophilic extract from Danshen, and lipophilic extract from Danshen	Constant speed and completed controlled release	(Zheng et al., 2013)
	Two-step release tablets	HPMC, PEG 4000, lactose, CMS, succinic acid, MCC, NaCl, and Pearlitol	Hydrophilic extract from Danshen, and lipophilic extract from Danshen, PNS, borneol	Zero-order release and pulse release	(Yuan et al., 2014)
Solid dispersions	Solid dispersions	PEG 6000, poloxamer 188, and PVP K30	Total TANs	Increased solubility and dissolution rate of Tan IIA and CPT	(Zhai et al., 2017)
	Solid dispersions	PVP10, and F127	Lipophilic extract from Danshen	Increased release of lipophilic components	(Xiong et al., 2011)
	Solid dispersions	GMS, and PEO	Total TANs	Increased dissolution and sustained release of TANs	(Chen et al., 2013)
Emulsions	Emulsions	soybean phospholipid, poloxamer 188, and glycerin	Tan ⅡA and Sal B	Long-term stability and loading of Tan ⅡA and Sal B simultaneously	(Wang et al., 2014)
Solid self- microemulsions	Solid self- microemulsions	Maisine 35–1, and IPM	Lipophilic extract from Danshen, and hydrophilic extract from Danshen	Improved oral bioavailability and storage stability	(Bi et al., 2016)
Liposomes	Liposomes	Phospholipid, and cholesterol	Total salvianolic acids	Sustained release of total salvianolic acids	(Zhang et al., 2007)
		Soybean phospholipid, and cholesterol	Glycyrrhetinic acid, Sal B, and Tan IIA	Increased bioavailability and water solubility	(Lin et al., 2014)
Hydrogel	Hydrogel	Octa-peptide FHFDFHFD	TANs	Increased loading capacity, sustained drug release and better anticancer capability	(Yin et al., 2017)