Table 2.
Putative targets of andrographolide against NASH.
| No. | Gene symbols | Protein names |
|---|---|---|
| 1 | ACE | Angiotensin-converting enzyme |
| 2 | ADH1A | Alcohol dehydrogenase 1A |
| 3 | ADH1C | Alcohol dehydrogenase 1C |
| 4 | AKT1 | RAC-alpha serine/threonine-protein kinase |
| 5 | CASP7 | Caspase-7 |
| 6 | CBS | Cystathionine beta-synthase |
| 7 | CD44 | CD44 antigen |
| 8 | CETP | Cholesteryl ester transfer protein |
| 9 | CHRNA4 | Neuronal acetylcholine receptor protein alpha-4 subunit |
| 10 | CTSD | Cathepsin D |
| 11 | DHFR | Dihydrofolate reductase |
| 12 | DPP4 | Dipeptidyl peptidase IV |
| 13 | ELANE | Leukocyte elastase |
| 14 | ERN1 | Serine/threonine-protein kinase/endoribonuclease IRE1 |
| 15 | F2 | Prothrombin |
| 16 | FABP1 | Fatty acid-binding protein, liver (by homology) |
| 17 | FABP4 | Fatty acid-binding protein, adipocyte |
| 18 | GSTM1 | Glutathione S-transferase Mu 1 |
| 19 | GSTP1 | Glutathione S-transferase P |
| 20 | HSD11B1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 |
| 21 | ICAM1 | Intercellular adhesion molecule (ICAM-1) |
| 22 | IGF1R | Insulin-like growth factor 1 receptor |
| 23 | IL10 | Interleukin-10 |
| 24 | IL1B | Interleukin-1 beta |
| 25 | IL6 | Interleukin-6 |
| 26 | INS | Insulin |
| 27 | MAPK8 | c-Jun N-terminal kinase 1 |
| 28 | MAPK9 | c-Jun N-terminal kinase 2 |
| 29 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 |
| 30 | NR1I3 | Nuclear receptor subfamily 1 group I member 3 |
| 31 | PON1 | Serum paraoxonase/arylesterase 1 |
| 32 | PRKCD | Protein kinase C delta |
| 33 | S100A9 | Protein S100-A9 |
| 34 | SERPINA1 | Alpha-1-antitrypsin |
| 35 | SOD1 | Superoxide dismutase [Cu-Zn] |
| 36 | SULT2A1 | Bile salt sulfotransferase |
| 37 | TNF | Tumor necrosis factor |
| 38 | TTR | Transthyretin |