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SAA significantly affected Ber absorption in small intestine. (A) HPLC chromatograms of Coptidis Rhizoma decoction (A1), Ber solution (A2) and SAA suspension (120 μg/mL) (A3). (B) Representative TEM image of SAA. (C) Ka and Papp variations of Ber absorption in the in situ intestinal perfusion model with different SAA concentrations. The data are expressed as mean ± SD (n = 5); *P < 0.05, **P < 0.01 and ***P < 0.001 vs Ber group.
