Fig. 4.

SAA dynamically regulated secretion of IFN-γ, IL-4, IL-17 and TGF-β in PPs. Representative immunohistochemistry staining images (A1-D1) and IOD analyses (A2-D2) of IFN-γ (A), IL-4 (B), IL-17 (C) and TGF-β (D) expression in PPs at 30, 60, 90 and 120 min after incubation with SAA, compared with which in groups NC and BC. Original magnification × 200. The data are expressed as mean ± SD (n = 5), with data obtained from 10 randomly selected fields in immunohistochemistry sections. *P < 0.05, ^**P < 0.01 and ^***P < 0.001 vs NC group.