Table 3.
Hypolipidemic activities of isolated compounds.
| No. | Compounds | IC50 values (µmol/L) | Taxon |
|---|---|---|---|
| 146 | Myricetrin | 97.35 ± 0.18 (α-glucosidase) | l |
| 147 | 5,8,3′,4′-Tetrahydroxy-flavone-7-O-β-D-xylopyranoside | 56.27 ± 0.13 (α-glucosidase) | l |
| 212 | 20(S)-Panaxadiol | 10.73 ± 0.21 (α-glucosidase); 10.77 ± 0.08 (PTP1B) | q |
| 212 | 20(S)-Panaxadiol | 22.72 ± 0.79 (α-glucosidase); 27.23 ± 2.36 (PTP1B) | r |
| 213 | Gypensapogenin A | 20.84 ± 0.28 (α-glucosidase); 37.46 ± 1.08 (PTP1B) | q |
| 214 | Gypensapogenin F | 21.66 ± 0.47 (α-glucosidase); 49.12 ± 0.36 (PTP1B) | q |
| 215 | 20(R)-Protopanaxadiol | 56.12 ± 0.26 (α-glucosidase); 62.19 ± 0.55 (PTP1B) | q |
| 216 | Gypsapogenin A | 2.50 ± 0.41 (α-glucosidase); 8.84 ± 0.12 (PTP1B) | q |
| 217 | (20S,24S)-3β,20,21β,23β,25-Pentahydroxy-21,24-epoxydammarane | 29.86 ± 0.24 (α-glucosidase); 15.02 ± 0.09 (PTP1B) | q |
| 218 | (23S)-3β-Hydroxydama-20,24-diene-21-carboxylic acid 21,23-lactone | 24.37 ± 0.19 (α-glucosidase); 20.65 ± 0.16 (PTP1B)I | q |
| 219 | (20R,23R)-3β,20-Dihydroxydammar-24-en-21-oic acid 21,23-lactone 3-O-[α-L-rhamnopyranosyl (1 → 2)] [β-D-xylopyranosyl ((1 → 3)]-6-O-acetyl-β-D-glucopyranoside | 27.41 ± 0.97 (α-glucosidase); 6.92 ± 0.18 (PTP1B) | q |
| 220 | (20R,23R)-19-oxo-3β,20-Dihydroxydammar-24-en-21-oci acid 21,23-lactone3-O-[α-L-rhamnopyranosyl-(1 → 2)] [β-D-xylopyranosyl (1 → 3)]-α-L-arabinopyranoside | 2.10 ± 0.83 (α-glucosidase); 1.07 ± 0.05 (PTP1B) | q |
| 221 | (20S,23S)-3β,20-Dihydroxydammar-24-en-21-oic acid 21,23-lactone 3-O-[α-L-rhamnopyranosyl (1 → 2)][β-D-xylopyranosyl (1 → 3)]-6-O-acetyl-β-D-glucopyranoside | 31.74 ± 0.89 (α-glucosidase); 33.88 ± 0.21 (PTP1B) | q |
| 222 | (20S,23S)-3β,20-Dihydroxydammar-24-en-21-oic acid and 21,23-lactone 3-O-[α-L-rhamnopyranosyl (1 → 2)] [β-D-xylopyranosyl-(1 → 3)]-β-D-glucopyranoside | 3.50 ± 0.12 (α-glucosidase); 8.91 ± 0.45 (PTP1B) | q |
| 223 | (20S)-3β,20,21-Trihydroxydammar-23,25-diene 3-O-{[α-L-rhamnopyranosyl (1 → 2)] [β-D-xylopyranosyl (1 → 3)]-β-D-glucopyranosyl}-21-O-β-D-glucopyranoside | 6.95 ± 0.31 (α-glucosidase); 18.23 ± 0.35 (PTP1B) | q |
| 224 | (20S,24R)-Dammarane-20,24-epoxy-3β,6α,12β,25-tetraol | >100 (α-glucosidase); 23.63 ± 5.09 (PTP1B) | |
| 225 | 20(R)-Dammarane-3β,12β,20,25-tetraol | 15.42 ± 0.87 (α-glucosidase); 10.39 ± 0.21 (PTP1B) | r |
| 226 | 20(S)-Dammarane-3β,6α,12β,20,25-pentol | 6.26 ± 1.59 (α-glucosidase); 6.21 ± 0.21 (PTP1B) | r |
| 227 | 20(R)-Dammarane-3β,12β,20,25-tetrahydroxy-3β-O-β-D- glucopyranoside | 0.22 ± 0.21 (α-glucosidase); 5.91 ± 0.38 (PTP1B) | r |
| 228 | β-Sitosterol | 69.41 ± 0.03 (α-glucosidase); > 100 (PTP1B) | r |
| 229 | Oleanolic acid | 1.04 ± 0.34 (α-glucosidase); 18.99 ± 1.46 (PTP1B) | r |
| 230 | 20(S)-Protopanaxadiol | 12.49 ± 1.22 (α-glucosidase); 13.38 ± 0.88 (PTP1B) | r |
| 231 | Ellagic acid | 72.3 ± 1.1 (DPP-4) | s |
| 232 | Quinic acid | 89.2 ± 1.1 (DPP-4) | s |
| 233 | 1-O-Caffeoyl-quinic acid | 103.4 ± 1.8 (DPP-4) | s |
Note: I IC50 value (mmol/L); II IC50 value (mg/mL).
Taxon: a Melaleuca alternifolia (Myrtaceae); b Mollugo pentaphylla (Aizoaceae); c Cynanchum auriculatum (Asclepiadaceae); d Sinopodophyllum hexandrum (Berberidaceae); e Trigonostemon lutescens (Euphorbiaceae); f Curcuma phaeocaulis (Zingiberaceae); g Chloranthus fortunei (Chloranthaceae); h Panax japonicus C. A. Mey. var. major (Nurkill) C. Y. Wu & K. M. Feng (Araliaceae); i Veratrum grandiflorum (Liliaceae); j endophytic fungus Aspergillus wentti Y1 isolated from Ainsliaea macrocephala (Compositae); k Dendrobium wardianum Warner (Orchidaceae); l Platycladus orientalis (Cupressaceae); m Stellera chamaejasme L. (Thymelaeaceae); n Azolla imbricata (Roxb.) Nakai (Azollaceae); o Lysiphyllum strychnifolium (Craib) A. Schmitz (Leguminosae); p Zanthoxylum schinifolium (Rutaceae); q Gynostemma pentaphyllum (Thunb.) Makion (Cucurbitaceae); r Panax quinquefolius (Araliaceae); s Phlomis tuberosa L. (Labiatae); t Aquilaria sinensis (Thymelaeceae); u marine fugus Aspergillus fumigatus MDCW-15; v endophytic fungus Aspergillus ochraceus SX-C7 from Selaginella stauntoniana (Selaginellaceae); w Aphanamixis sinensis (Meliaceae).