Table 1. Summary of the studies: prognosis according to CD44+/CD24- BCSC marker expression.
Author | Year | Study population | Findings |
Chekhun et al. [29] | 2015 | 132 patients with BC stage 1-2 | Statistical significance was found between the presence of CD44+/CD24- in metastatic regional lymph nodes along with overall survival (OS) in cases with basal-like and molecular subcategories |
Li et al. [30] | 2010 | Immunohistochemistry of 103 cases of invasive micropapillary carcinoma (IMPC) and 94 cases of invasive ductal carcinoma (IDC) | CD44+/CD24- marker was observed in tumor cells in micropapillary and also in its stroma. Moreover, CD44+/CD24- was related to lymphovascular invasion, lymph node, and distant metastasis |
Giatromanolaki et al. [31] | 2010 | 139 cases of breast carcinomas (IDC) were investigated in paraffin sections using cell-like markers: (CD44, CD24), the ‘‘triple-state’’ (ER, PR, c-erb-B2), and angiogenesis (CD31) | Cases with CD44+/CD24- profile had a lower median age at onset of BC and showed a triple-negative state. They had a poor prognosis |