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. 2022 Aug 28;28(32):4540–4556. doi: 10.3748/wjg.v28.i32.4540

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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A 47 mm liver mass was incidentally found, in a 40-year-old man with beta thalassemia, during cardiac magnetic resonance investigation for myocardial iron overload. A-C: On abdominal magnetic resonance imaging, the lesion demonstrated high signal intensity on T2 weighted image (A), arterial phase hyperenhancement on post-contrast arterial phase (B), and washout on portal phase (C). Although there are no current evidence-based guidelines for patients with beta thalassemia without cirrhosis, the hepatologist confirmed the patient’s risk status and proposed that Liver Imaging Reporting and Data System (LI-RADS) should be applied. According to the LI-RADS criteria, the lesion was categorized as LR-5 (definite hepatocellular carcinoma); D: Unenhanced computed tomography scan after transarterial chemoembolization showed accumulation of iodized oil (arrow) within the tumor.