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. 2022 Sep 15;18(9):e10514. doi: 10.15252/msb.202110514

Figure 1. Illustration of the core GPCR signaling pathway and the analogous model.

Figure 1

  • A
    Key components of the GPCR signaling pathway. Dashed lines mark canonical GPCR pathways, though they have not been verified yet in the AWA neuron.
  • B
    An analogous circuit topology that recapitulates the main signaling events related to calcium dynamics. Note that S (TRPV and VGCC) depicts a self‐amplifying module to generate the pulsatile activity. Symbols next to arrows mark the relevant constant in the model's equations. Blue arrows indicate activation, and red lines mark inhibition.