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. 2022 Aug 24;90(9):e00309-22. doi: 10.1128/iai.00309-22

FIG 3.

FIG 3

Modulation of innate immune factor production by Lcr35 under the control of SLPI production in G. vaginalis-infected cells. VK2/E6E7 cells were infected with G. vaginalis (MOI, 10) alone or with Lcr35 at different MOIs (MOI, 1 to 100). (A) SLPI concentration was analyzed 6 h postinfection by ELISA. Recombinant SLPI protein was added to VK2/E6E7 cells incubated with G. vaginalis (MOI, 10) and Lcr35 (MOI, 10). (B) IL-8, HBD-2, and IL-1β concentrations were detected by ELISA in supernatants after 6 h of incubation. Values are the means ± SEM; n = 3 to 4; $$, P < 0.05 compared with uninfected cells; *, P < 0.05; **, P < 0.01 compared with G. vaginalis-infected cells. #, P < 0.05; #, P < 0.01 compared with vaginal cells infected with G. vaginalis and Lcr35.