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Model for immunostimulatory effect of Lcr35 on G. vaginalis-infected vaginal epithelial cells. G. vaginalis induces the secretion of SLPI, which interacts with the NF-κB pathway and can inhibit immune cell recruitment (A). Lcr35 counteracts these immunosuppressive effects by SLPI inhibition, which leads to secretion of immunostimulatory cytokines and defensins and an increase in immune cell (e.g., dendritic cells) recruitment (B).
