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. 2022 Sep 15;12(40):26116–26122. doi: 10.1039/d2ra03506e

The rate constant of the M6 reactants combine with different nucleophile groups to form target products.

Species Yield Energy barrier (kcal mol−1) k TS4 (s−1)
HN-2A 90% −4.6 1.6 × 10−6
2A-OH 77% 2.7 8.6 × 10−8
N-2A 19% 2.6 9.0 × 10−8
HO-2A 6% 2.6 9.0 × 10−8