Table 3.
Top-ranked enriched downregulated protein domains. The four specific protein domains related to the CK kinase family (IPR000719, IPR011009, IPR008271, and IPR017441) are ranked among the top ones. The Statistic column depicts the z-score of the enrichment analysis, the P-value column shows its corresponding P-value, Description column includes a brief description of each protein domain, and the Ranking column the position in the ranking of the most down-regulated protein domains
| PROTEIN DOMAIN | Statistic | P-value | Description | Ranking |
|---|---|---|---|---|
| IPR016024 | -14.18 | 1.51 e-45 | Armadillo-type fold | 1/5783 |
| IPR027417 | -12.95 | 2.80 e-38 | P-loop containing nucleoside triphosphate hydrolase | 2/5783 |
| IPR017986 | -11.23 | 3.35 e-29 | WD40-repeat-containing domain | 3/5783 |
| IPR011993 | -11.12 | 1.08 e-28 | PH domain-like | 4/5783 |
| IPR000719 | -10.75 | 2.07 e-14 | Protein kinase domain | 5/5783 |
| IPR011009 | -10.03 | 2.63 e-13 | Protein kinase-like domain | 6/5783 |
| ··· | ··· | ··· | ··· | ··· |
| IPR008271 | -8.13 | 4.46 e-09 | Serine/threonine-protein kinase, active site | 14/5783 |
| ··· | ··· | ··· | ··· | ··· |
| IPR017441 | -6.35 | 5.55 e-09 | Protein kinase, ATP binding site | 23/5783 |