TABLE 2.
Overall Costs of PGx-testing, pharmacist and physician time for interpretation and drug treatment.
| Drug | N drug Initiators | Cost of PGx Test/€ per Initiator | Average Cost of HCP Interpretation of Actionable PGx Result/€ per Initiator a | Average Cost of Drugs for Standard of Care (SoC) Treatment/€ per Initiator in 1 year | Average Cost of Drugs for PGx-Guided Treatment/€ per Initiator in 1 year | Difference in Average Drug Costs b (SoC-PGx) (% Saved)/€ per Initiator in 1 year | Total Costs for all initiators c /€ |
|---|---|---|---|---|---|---|---|
| Azathioprine | 6,979 | 132 | 1 | 248 | 237 | 11 (4.6%) | 854,659 |
| Capecitabine | 8,860 | 132 | 1 | 1,204 | 1,158 | 46 (3.9%) | 775,246 |
| Clopidogrel | 117,900 | 132 | 5 | 15 | 38 | −24 (−62%) | 18,923,430 |
| Fluorouracil (systemic) | 6,765 | 132 | 1 | 82 | 79 | 3 (4.0%) | 880,112 |
| Irinotecan | 2,593 | 66 | 2 | 14,842 | 14,588 | 253 (1.7%) | -481,019 |
| Mercaptopurine | 2,177 | 132 | 1 | 1,956 | 1,875 | 81 (4.3%) | 114,172 |
| Tioguanine | 2,854 | 132 | 1 | 1,088 | 1,080 | 7 (0.7%) | 359,471 |
| TOTAL for all initiators/€ | 148,128 | 19,381,790 | 586,167 | 60,519,056 | 61,977,169 | −1,458,113 | 21,426,070 |
| Mean per initiator/€ | - | 131 | 16 a | 409 | 418 | 10 | 145 |
PGx, pharmacogenomic.
a
Note: only those with an actionable drug-gene interaction will be interpreted by an HCP.
b
[cost drugsstandard of care]-[cost drugsPGx-guided]*[Ndrug initiators].
c
[costPGxtest]+[costpharmacist and physician time]-[costdrugs].