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. 2022 Sep 1;13:849014. doi: 10.3389/fphar.2022.849014

FIGURE 2.

FIGURE 2

SM934 restored the intestinal barrier and reduced abnormal epithelial proliferation in TNBS-induced colitis mice. (A) Serum FITC-dextran fluorescence intensity was used to observe the intestinal permeability (n = 4). (B) Representative images of the positive staining area of E-cadherin with immunohistochemical staining (scare bar, 100 µm), right; the positive area was analyzed (left). (C) Western blotting assayed the expressions of E-cadherin/β-catenin/occludin in colon tissue. (D) Relative intensity of protein to GAPDH. Data are shown as means ± SEM (n = 3). (E) Representative images of colon sections stained with the proliferation marker Ki67 (Scale bar, 100 µm), right; the number of Ki67-positive cells was counted, left. # p < 0.05; ### p < 0.001 vs. normal group; *p < 0.05, **p < 0.01, and ***p < 0.001 vs. vehicle group.