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. 2022 Sep 11;15:5247–5263. doi: 10.2147/JIR.S377499

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© 2022 Luo et al.

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Depletion of C/EBPβ led to recovery from LPS-induced inflammatory injury in alveolar macrophages. (A) RT-qPCR was utilized to detect C/EBPβ mRNA level in LPS-treated NR8383 cells transfected with sh-C/EBPβ. (B–D) Levels of pro-inflammatory factors IL-6, TNF-α and IL-1β were assessed utilizing commercial assay kits in NR8383 cells. (E) The protein levels of C/EBPβ, iNOS and IL-1β were measured by Western blotting. (F and G) Transfected with sh-NC or sh-C/EBPβ, NR8383 cells treated by LPS underwent RT-qPCR analysis for iNOS and IL-1β expression. *p < 0.05, **p < 0.01, and ***p < 0.001 compared with the CON group. ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001 compared with the LPS + sh-NC group.