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. 2022 Sep 11;15:5247–5263. doi: 10.2147/JIR.S377499

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© 2022 Luo et al.

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C/EBPβ targets the NOD2/RIPK2/NF-κB pathway to regulate IL-1β transcription and secretion. (A–C) The protein and mRNA levels of NOD1 and NOD2 were detected using WB and RT-qPCR in LPS-treated NR8383 cells transfected with sh-NC or sh-C/EBPβ. (D) The agonistic effect of MDP on NOD2 receptor was detected by RT-qPCR. (E and F) The level of IL-1β was detected via RT-qPCR and ELISA in response to sh-C/EBPβ or sh-C/EBPβ + MDP in LPS-induced NR8383 cells. (G and H) WB and its histogram were used to assess the expression levels of NOD2, RIPK2, p-RIPK2, NF-κB p65, NF-κB p-p65, Pro-IL-1β and IL-1β p17 in LPS-intoxicated NR8383 cells transfected with different plasmids. *p < 0.05, **p < 0.01, and ***p < 0.001 compared with the CON group. ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001 compared with the LPS/LPS + sh-NC group. ^p < 0.05, ^^p < 0.01, ^^^p < 0.001 compared with the LPS + sh-C/EBPβ group.