Table 4.
Toxicity of the Top 20 Compounds and Helenalin
| Compounds | Mouse NTPa | Rat NTPa | Amesb | DTPc | ||
|---|---|---|---|---|---|---|
| Female | Male | Female | Male | |||
| ZINC000003637160 | 0 | 0 | 0 | 0 | 0 | 1 |
| ZINC000014774634 | 0 | 0 | 0 | 0 | 0 | 0 |
| ZINC000006094027 | 0 | 0 | 0 | 0 | 0 | 1 |
| ZINC000013412042 | 0 | 1 | 0 | 1 | 0 | 1 |
| ZINC000012958448 | 0 | 0 | 0 | 1 | 0 | 1 |
| ZINC000019796031 | 1 | 1 | 1 | 1 | 0 | 0 |
| ZINC000004544883 | 0 | 0 | 1 | 0 | 0 | 0 |
| ZINC000004655405 | 0 | 1 | 1 | 0 | 0 | 0 |
| ZINC000000039452 | 0 | 0 | 1 | 0 | 0 | 1 |
| ZINC000013436567 | 0 | 0 | 1 | 1 | 0 | 1 |
| ZINC000014947781 | 0 | 1 | 1 | 0 | 0 | 0 |
| ZINC000014763050 | 0 | 1 | 1 | 0 | 0 | 1 |
| ZINC000008220075 | 0 | 0 | 1 | 1 | 0 | 0 |
| ZINC000014819637 | 0 | 1 | 1 | 0 | 0 | 1 |
| ZINC000015115226 | 0 | 1 | 1 | 0 | 0 | 1 |
| ZINC000014824077 | 0 | 0 | 1 | 0 | 0 | 0 |
| ZINC000004096962 | 0 | 0 | 1 | 0 | 0 | 1 |
| ZINC000001531449 | 0 | 0 | 1 | 0 | 0 | 1 |
| ZINC000043200202 | 0 | 1 | 1 | 0 | 0 | 0 |
| ZINC000014762603 | 0 | 1 | 1 | 0 | 0 | 1 |
| Helenalin | 0 | 1 | 1 | 0 | 0 | 1 |
Notes: a0, Non-carcinogen; 1, Carcinogen. b0, Non-mutagen; 1, Mutagen. c0, Nontoxic; 1, Toxic.