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. 2022 Sep 15;17(9):e0274582. doi: 10.1371/journal.pone.0274582

Fig 1. rmIL-23 administration induces RORγt proliferation in liver.

Fig 1

FACS staining was performed in liver NPCs isolated from mice administered either PBS or recombinant mouse IL-23 (rmIL-23) by IP injections (A-G): Representative FACS gate, IL-23 induced greater frequency of RORγt+Ki67+ T Cells gated from CD3e+CD4-CD8- (A). Total RORγt+Ki67+ T Cells, indication of proliferative cell, and total RORγt (CD4-CD3-) T Cells quantified in the liver (B-C). Percentage quantification of Ki67+ of RORγt+MAITs and RORγt+ γδ T Cells (D-E). Percentage of Neutrophils and Ly6c+ monocytes from CD45+ Cells (F-G). Groups: Vehicle (PBS): n = 6, rmIL-23 (3x 0.5ug): n = 6. Data represents mean ± S.D. *p < 0.05, **p < 0.001, ****p < 0.0001, two-tailed t-test.