Fig 7. Schematic of Ptprh mutant mouse tumors failing to dephosphorylate EGFR.

Ordinarily, PTPRH is responsible for regulating EGFR signaling through dephosphorylation of tyrosine residues on the C-terminal tail of EGFR. We have shown PTPRH mutant mouse tumors and PTPRH KO human cells to have increased phosphorylation of EGFR, and subsequent increased activation of the PI3K/AKT pathway.