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. 2022 Sep 2;18(9):e1010809. doi: 10.1371/journal.ppat.1010809

Fig 8. Mice deficient in LCN2 expression have increased susceptibility to A. baumannii pneumonia.

Fig 8

Lcn2-/- knockout mice and their WT C57BL/6 littermate controls were infected intranasally with WT A. baumannii. The infection was allowed to proceed for 36 h before the mice were humanely euthanized and the organs were harvested. Organs were homogenized, serially diluted in PBS and plated to LBA. The bacterial burdens of the kidneys (A), heart (B), liver (C), spleen (D), lungs (E), and blood (F) were determined. Each symbol represents the WT A. baumannii count in the corresponding organ of one animal. Data are compiled from two independent experiments. Statistical significance was determined by Mann-Whitney U test, where *p < 0.05, ** p < 0.01, and *** p < 0.001. The dashed line represents the limit of detection for the assay.