Table 3. The percentage change of the cognitive decline by the end of the 78-week treatment period for the LMCI group.
| Subject # | Starting at Age 60 | Starting at Age 70 | ||||
|---|---|---|---|---|---|---|
| Aducanumab | Donanemab | Aducanumab | Donanemab | |||
| Low dose | High dose | Low dose | High dose | |||
| MCI1 | 0.1 | 0.14 | 0.86 | 9.7 × 10−3 | 1.3 × 10−2 | 8.4 × 10−2 |
| MCI2 | 5.9 × 10−2 | 7.9 × 10−2 | 0.45 | 2.5 × 10−2 | 3.3 × 10−2 | 0.2 |
| MCI3 | 0.12 | 0.16 | 1 | 1.6 × 10−2 | 2.1 × 10−2 | 0.14 |
| MCI4 | 4.3 × 10−6 | 6.1 × 10−6 | 3.3 × 10−5 | NR | NR | NR |
| MCI5 | 1.6 × 10−3 | 2.2 × 10−3 | 1.3 × 10−2 | 4.7 × 10−6 | 6.3 × 10−6 | 4.7 × 10−5 |
| MCI6 | 1.9 × 10−3 | 2.4 × 10−3 | 1.8 × 10−2 | 7.6 × 10−7 | 9.7 × 10−7 | 7.8 × 10−6 |
| MCI7 | 1.1 × 10−2 | 1.4 × 10−2 | 8.9 × 10−2 | 9.6 × 10−3 | 1.3 × 10−2 | 8.2 × 10−2 |
| MCI8 | 0.14 | 0.19 | 1.2 | 2.9 × 10−2 | 3.8 × 10−2 | 0.25 |
| MCI9 | 4.1 × 10−4 | 5.8 × 10−4 | 3.2 × 10−3 | 2.4 × 10−4 | 3.3 × 10−4 | 2 × 10−3 |
| MCI10 | 8.3 × 10−7 | 1.1 × 10−6 | 6.8 × 10−6 | NR | NR | NR |
| MCI11 | 2.5 × 10−4 | 3.5 × 10−4 | 2 × 10−3 | 10−15 | 2 × 10−5 | NR |
| MCI12 | 1.2 × 10−2 | 1.5 × 10−2 | 9.9 × 10−2 | 2.8 × 10−4 | 3.6 × 10−4 | 2.5 × 10−3 |
| MCI13 | 0.11 | 0.15 | 0.92 | 1.2 × 10−2 | 1.6 × 10−2 | 0.1 |
| MCI14 | 4.8 × 10−3 | 6.5 × 10−3 | 3.7 × 10−2 | 5.7 × 10−3 | 7.5 × 10−3 | 4.5 × 10−2 |
| MCI15 | NR | NR | NR | NR | NR | NR |
| MCI16 | 3.6 × 10−2 | 5 × 10−2 | 0.3 | 1.4 × 10−4 | 1.9 × 10−4 | 1.4 × 10−3 |
| MCI17 | 7.4 × 10−7 | 9.5 × 10−7 | 8.5 × 10−6 | NR | NR | NR |
| MCI18 | 1.7 × 10−3 | 2.2 × 10−3 | 1.4 × 10−2 | 1.6 × 10−3 | 2 × 10−3 | 1.3 × 10−2 |
| MCI19 | 6.2 × 10−2 | 8.4 × 10−2 | 0.47 | 3.7 × 10−2 | 5.1 × 10−2 | 0.29 |
| MCI20 | 5.1 × 10−2 | 6.7 × 10−2 | 0.42 | 1.4 × 10−2 | 1.8 × 10−2 | 0.12 |
| MCI21 | 2.3 × 10−2 | 3.2 × 10−2 | 0.18 | 2.2 × 10−2 | 3 × 10−2 | 0.17 |
| MCI22 | 1.9 × 10−6 | 2.5 × 10−6 | 2.1 × 10−5 | NR | NR | NR |
| MCI23 | 4.5 × 10−3 | 5.9 × 10−3 | 3.7 × 10−2 | 4.2 × 10−3 | 5.4 × 10−3 | 3.6 × 10−2 |
| MCI24 | 1.2 × 10−5 | 1.6 × 10−5 | NR | NR | NR | NR |
| MCI25 | 4.4 × 10−3 | 6.1 × 10−3 | 3.7 × 10−2 | 1.8 × 10−5 | 2.4 × 10−5 | 1.8 × 10−4 |
| MCI26 | 0.13 | 0.17 | 1 | 2.4 × 10−2 | 3.1 × 10−2 | 0.2 |
| MCI27 | 7.6 × 10−3 | 10−2 | 6.4 × 10−2 | 6.3 × 10−3 | 8.1 × 10−3 | 5.3 × 10−2 |
| MCI28 | 1.7 × 10−3 | 2.3 × 10−3 | 1.4 × 10−2 | NR | NR | 3.1 × 10−7 |
| MCI29 | 0.28 | 0.4 | 2.2 | 0.16 | 0.23 | 1.3 |
| MCI30 | 0.12 | 0.16 | 0.92 | 2.8 × 10−2 | 3.8 × 10−2 | 0.22 |
| MCI31 | 0.14 | 0.19 | 1.1 | 4 × 10−2 | 5.2 × 10−2 | 0.32 |
| MCI32 | 0.1 | 0.15 | 1 | 5 × 10−2 | 4 × 10−2 | 0.25 |
| Median | 0.12 | 0.16 | 0.92 | 0.16 | 0.23 | 0.21 |