Skip to main content
. 2022 Sep 2;18(9):e1010481. doi: 10.1371/journal.pcbi.1010481

Table 4. The percentage change of the cognitive decline by the end of the 10-year treatment period for the LMCI group.

Subject # Starting at Age 60 Starting at Age 70
Aducanumab Donanemab Aducanumab Donanemab
Low dose High dose Low dose High dose
MCI1 3.4 5.1 15 0.33 0.49 1.2
MCI2 5.7 7.8 16 2.8 3.8 8.2
MCI3 4.6 6.9 18 0.55 0.83 2
MCI4 NR NR NR NR NR NR
MCI5 0.12 0.19 0.53 2.5 × 10−5 3.3 × 10−5 4.3 × 10−5
MCI6 1.4 × 10−2 2.2 × 10−2 3.4 × 10−2 3.3 × 10−6 5.3 × 10−6 3.2 × 10−6
MCI7 1.9 2.7 5.7 1.3 1.9 4.2
MCI8 7.4 11 27 2.1 3.1 8.1
MCI9 0.12 0.17 0.32 1 × 10−2 1.8 × 10−2 2.9 × 10−2
MCI10 NR NR 5.1 × 10−7 NR NR NR
MCI11 NR NR 1.2 × 10−6 NR NR 2.2 × 10−7
MCI12 1.1 × 10−7 5 × 10−7 5.7 × 10−6 NR NR 3.5 × 10−7
MCI13 0.18 0.28 0.71 2.5 × 10−3 4 × 10−3 4.3 × 10−2
MCI14 3.6 5.4 15 0.26 0.4 0.88
MCI15 1.1 1.5 2.7 1.1 1.5 2.7
MCI16 1.8 × 10−7 2.9 × 10−7 1.9 × 10−6 NR NR NR
MCI17 0.89 1.6 6.5 4.2 × 10−4 5.9 × 10−4 1.5 × 10−3
MCI18 7.5 × 10−7 9.2 × 10−7 1.1 × 10−6 NR NR NR
MCI19 0.29 0.42 0.73 0.24 0.35 0.63
MCI20 7.3 9.8 19 4.9 6.5 13
MCI21 4 5.9 16 1 1.5 4.1
MCI22 4.3 5.8 11 3.3 4.5 9.1
MCI23 3.8 × 10−6 4.7 × 10−6 7.2 × 10−5 NR NR NR
MCI24 0.82 1.2 2.4 0.62 0.91 1.9
MCI25 NR NR NR NR NR NR
MCI26 0.12 0.2 0.53 6.8 × 10−5 1 × 10−4 3.2 × 10−3
MCI27 6.3 9.3 24 1.7 2.5 6.6
MCI28 1.2 1.8 4 0.88 1.3 2.9
MCI29 9.1 × 10−5 1.5 × 10−4 1.4 × 10−3 NR NR NR
MCI30 21 31 55 8.8 14 31
MCI31 7.9 11 23 2.2 3.1 6.8
MCI32 9.2 13 27 3.5 5 11
Median 3.5 5.3 13 1.3 1.9 4.2