Table 4. The percentage change of the cognitive decline by the end of the 10-year treatment period for the LMCI group.
Subject # | Starting at Age 60 | Starting at Age 70 | ||||
---|---|---|---|---|---|---|
Aducanumab | Donanemab | Aducanumab | Donanemab | |||
Low dose | High dose | Low dose | High dose | |||
MCI1 | 3.4 | 5.1 | 15 | 0.33 | 0.49 | 1.2 |
MCI2 | 5.7 | 7.8 | 16 | 2.8 | 3.8 | 8.2 |
MCI3 | 4.6 | 6.9 | 18 | 0.55 | 0.83 | 2 |
MCI4 | NR | NR | NR | NR | NR | NR |
MCI5 | 0.12 | 0.19 | 0.53 | 2.5 × 10−5 | 3.3 × 10−5 | 4.3 × 10−5 |
MCI6 | 1.4 × 10−2 | 2.2 × 10−2 | 3.4 × 10−2 | 3.3 × 10−6 | 5.3 × 10−6 | 3.2 × 10−6 |
MCI7 | 1.9 | 2.7 | 5.7 | 1.3 | 1.9 | 4.2 |
MCI8 | 7.4 | 11 | 27 | 2.1 | 3.1 | 8.1 |
MCI9 | 0.12 | 0.17 | 0.32 | 1 × 10−2 | 1.8 × 10−2 | 2.9 × 10−2 |
MCI10 | NR | NR | 5.1 × 10−7 | NR | NR | NR |
MCI11 | NR | NR | 1.2 × 10−6 | NR | NR | 2.2 × 10−7 |
MCI12 | 1.1 × 10−7 | 5 × 10−7 | 5.7 × 10−6 | NR | NR | 3.5 × 10−7 |
MCI13 | 0.18 | 0.28 | 0.71 | 2.5 × 10−3 | 4 × 10−3 | 4.3 × 10−2 |
MCI14 | 3.6 | 5.4 | 15 | 0.26 | 0.4 | 0.88 |
MCI15 | 1.1 | 1.5 | 2.7 | 1.1 | 1.5 | 2.7 |
MCI16 | 1.8 × 10−7 | 2.9 × 10−7 | 1.9 × 10−6 | NR | NR | NR |
MCI17 | 0.89 | 1.6 | 6.5 | 4.2 × 10−4 | 5.9 × 10−4 | 1.5 × 10−3 |
MCI18 | 7.5 × 10−7 | 9.2 × 10−7 | 1.1 × 10−6 | NR | NR | NR |
MCI19 | 0.29 | 0.42 | 0.73 | 0.24 | 0.35 | 0.63 |
MCI20 | 7.3 | 9.8 | 19 | 4.9 | 6.5 | 13 |
MCI21 | 4 | 5.9 | 16 | 1 | 1.5 | 4.1 |
MCI22 | 4.3 | 5.8 | 11 | 3.3 | 4.5 | 9.1 |
MCI23 | 3.8 × 10−6 | 4.7 × 10−6 | 7.2 × 10−5 | NR | NR | NR |
MCI24 | 0.82 | 1.2 | 2.4 | 0.62 | 0.91 | 1.9 |
MCI25 | NR | NR | NR | NR | NR | NR |
MCI26 | 0.12 | 0.2 | 0.53 | 6.8 × 10−5 | 1 × 10−4 | 3.2 × 10−3 |
MCI27 | 6.3 | 9.3 | 24 | 1.7 | 2.5 | 6.6 |
MCI28 | 1.2 | 1.8 | 4 | 0.88 | 1.3 | 2.9 |
MCI29 | 9.1 × 10−5 | 1.5 × 10−4 | 1.4 × 10−3 | NR | NR | NR |
MCI30 | 21 | 31 | 55 | 8.8 | 14 | 31 |
MCI31 | 7.9 | 11 | 23 | 2.2 | 3.1 | 6.8 |
MCI32 | 9.2 | 13 | 27 | 3.5 | 5 | 11 |
Median | 3.5 | 5.3 | 13 | 1.3 | 1.9 | 4.2 |