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. 2021 Dec 17;2(1):22–35. doi: 10.1021/acsbiomedchemau.1c00048

Figure 1.

Figure 1

Despite high diversity in sequence and reaction outcome, all members of the RSS generate 5′-deoxyadenosyl (5′-dA) radical using a conserved [4Fe–4S]-forming motif that binds and reductively liberates Met from SAM.47 RadicalSAM.org provides easy access to a genomic enzymology strategy to catalog known enzymatic activities and discover new ones within the RSS.