Table 2.
Differences in Antituberculosis Drug Resistance Mutations Among Paired Mycobacterium tuberculosis Strains, According to Tuberculosis Treatment Outcome (n = 21)
| Patient ID | Origin | Outcome Timing | TB Drug Resistance Pattern, Mutation (TB Drug) | |
|---|---|---|---|---|
| Baseline | Follow-up | |||
| Treatment failure | ||||
| 1 | Pune | Month 5 | gyrA (ciprofloxacin/moxifloxacin/ofloxacin, fluoroquinolones, levofloxacin) | gyrA (ciprofloxacin/moxifloxacin/ofloxacin, fluoroquinolones, levofloxacin) |
| 2 | Pune | Month 6 | gyrA (ciprofloxacin/moxifloxacin/ofloxacin, fluoroquinolones, levofloxacin) | gyrA (ciprofloxacin/moxifloxacin/ofloxacin, fluoroquinolones, levofloxacin) |
| 3 | Pune | Month 6 | None | Rrs (capreomycin, kanamycin, aminoglycosides, amikacin) gyrA (fluoroquinolones, levofloxacin, ofloxacin, ciprofloxacin) |
| 4 | Pune | Month 5 |
rpoB (rifampicin) fabG1 (isoniazid, isoniazid) pncA (pyrazinamide) |
None |
| 5 | Pune | Month 6 | gyrA (ciprofloxacin/moxifloxacin/ofloxacin, fluoroquinolones, levofloxacin) | None |
| 6 | Pune | Month 5 |
rpoB (rifampicin) fabG1 (isoniazid, ethionamide) pncA (pyrazinamide) |
None |
| 7a | Chennai | Month 5 | None | katG (isoniazid) |
| 8 | Pune | Month 5 | ahpC (isoniazid) | ahpC (isoniazid) |
| 9a | Pune | Month 5 | ethA (ethionamide) | ethA (ethionamide) |
| 10a | Chennai | Month 6 | None | ethA (ethionamide) |
| Recurrence | ||||
| 11 | Pune | Month 12 | gyrA (ciprofloxacin/moxifloxacin/ofloxacin, fluoroquinolones, levofloxacin) | gyrA (ciprofloxacin/moxifloxacin/ofloxacin, fluoroquinolones, levofloxacin) |
| 12 | Pune | Month 12 |
katG (isoniazid) gyrB (fluoroquinolones, levofloxacin, moxifloxacin, ofloxacin, ciprofloxacin) ethA (ethionamide) |
katG (isoniazid) gyrB (fluoroquinolones, levofloxacin, moxifloxacin, ofloxacin, ciprofloxacin) ethA (ethionamide) |
| 13 | Pune | Month 12 | fabG1 (isoniazid) | fabG1 (isoniazid) |
| 14 | Chennai | Month 18 |
katG (isoniazid) embB (ethambutol) |
katG (isoniazid) embB (ethambutol) |
| 15a | Chennai | Month 18 | None |
katG (isoniazid) pncA (pyrazinamide) rpoB (rifampin) |
| 16a | Pune | Month 18 | gyrA (ciprofloxacin/moxifloxacin/ofloxacin, fluoroquinolones, levofloxacin) | gyrA (ciprofloxacin/moxifloxacin/ofloxacin, fluoroquinolones, levofloxacin) |
| 17 | Pune | Month 12 | None |
gid (streptomycin) KatG (isoniazid) |
| 18 | Pune | Month 18 | gyrA (ciprofloxacin/moxifloxacin/ofloxacin, fluoroquinolones, levofloxacin) | None |
| 19a | Chennai | Month 9 | None | ethA (ethionamide) |
| 20a | Chennai | Month 7 | ethA (ethionamide) | ethA (ethionamide) |
| 21 | Chennai | Month 7 | ethA (ethionamide) | ethA (ethionamide) |
Abbreviations: ID, identification; TB, tuberculosis.
Represents patients with TB and diabetes mellitus.