TABLE 3.

Inflammatory and immune markers in critically ill patients undergoing cardiac surgery.

Variable	Total, n (%)	Delirium, n (%)	No delirium, n (%)	P-value
Inflammatory markers
Interleukin-6, pg/mL, Mdn (IQR)	208.7 (346.7)	247.2 (383.3)	178.0 (274.1)	0.009${}^{\underset{¯}{a}}$
Interleukin-8, pg/mL, Mdn (IQR)	89.0 (105.0)	101.0 (108.3)	74.0 (97.0)	0.029${}^{\underset{¯}{a}}$
Interleukin-10, pg/mL, Mdn (IQR)	9.9 (10.6)	10.0 (10.8)	9.6 (10.1)	0.668
Tumor necrosis factor-α, pg/mL, Mdn (IQR)	11.3 (6.9)	12.3 (6.2)	8.9 (5.6)	<0.001${}^{\underset{¯}{a}}$
Neutrophil count, × 10^9/L, mean (SD)	11.74 (4.99)	12.01 (5.27)	11.27 (4.45)	0.143
Lymphocyte count, × 10^9/L, mean (SD)	1.16 (0.43)	1.18 (0.43)	1.12 (0.43)	0.143
NLR, Mdn (IQR)	10.17 (5.60)	10.23 (5.64)	10.00 (5.39)	0.698
hsCRP, mg/dL, Mdn (IQR)	121.8 (152.06)	140.76 (163.68)	113.95 (113.14)	0.094
PCT, ng/L, mean (SD)	10.64 (29.07)	10.72 (18.26)	10.50 (42.00)	0.943
Immune parameters, g/L, mean (SD)
Immunoglobulin A	1.91 (0.77)	1.90 (0.76)	1.92 (0.78)	0.751
Immunoglobulin G	8.52 (3.02)	8.33 (2.92)	8.84 (3.20)	0.122
Immunoglobulin M	0.72 (0.45)	0.71 (0.44)	0.74 (0.47)	0.602
Complement 3	0.773 (0.217)	0.760 (0.234)	0.796 (0.181)	0.097
Complement 4	0.157 (0.056)	0.155 (0.059)	0.160 (0.052)	0.361
Lymphocyte subsets, Mdn (IQR)
Natural killer cell count, cells/μL	92 (89)	94 (84)	86 (95)	0.211
CD19 + B cell count, cells/μL	129 (142)	145.5 (160)	105 (111)	0.004${}^{\underset{¯}{a}}$
CD3 + T cell count, cells/μl	827 (328)	844.5 (281)	809 (463)	0.058
CD4 + T cell count, cells/μl	528 (301)	566 (182)	339 (253)	<0.001${}^{\underset{¯}{a}}$
CD8 + T cell count, cells/μl	251 (147)	251.5 (134)	244 (207)	0.690
CD4/CD8 ratio	1.93 (1.16)	2.31 (1.00)	1.28 (0.83)	<0.001${}^{\underset{¯}{a}}$

${}^{\underset{¯}{a}}$Statistically significant (P < 0.05).

IQR, interquartile range; hsCRP, hypersensitive C-reactive protein; PCT, procalcitonin; NLR, neutrophil to lymphocyte ratio; SD, standard deviation.