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. 2021 Oct 26;10:e66039. doi: 10.7554/eLife.66039

Figure 53. A direct pathway linking sleep-wake neurons in the dorsal fan-shaped body (dFB) and ellipsoid body (EB).

Network graph showing the connections between ExR1, ExR3, and hΔK, along with some of their major upstream and downstream connections in the dFB (top panel) and EB (bottom panel). dFB types contained in the R23E10 line have "(sleep)" below their name, while the wake-promoting dopaminergic types have "(DAN)". Note that these circuits are embedded in the highly recurrent dFB and RB networks, whose many neuron types and connections have been omitted for clarity.

Figure 53.

Figure 53—figure supplement 1. Ellipsoid body (EB) neuron types in 5HT7-GAL4.

Figure 53—figure supplement 1.

(A) Front view of a 3D rendering of a confocal stack showing the expression pattern of 5HT7-GAL4, which contains EB neuron types that express the serotonin 5HT7 receptor and receive input from ExR3 (Liu et al., 2019). 5HT7-GAL4 labels neurons in the ER3d, ER3p, and ER4d populations. (B) Morphological rendering of ER3d (a–d) EM morphologies overlaid on 5HT7-GAL4 expression pattern. Individual neurons. ER3d_a (1261086734), ER3d_b (1261427885), ER3d_c (1261419142), and ER3d_d (1261423534). (C) Morphological rendering of ER3p (a–b) EM morphologies overlaid on 5HT7-GAL4 expression pattern. Individual neurons: ER3p_a (1229288307) and ER3p_b (1260327246). (D) Morphological rendering of ER4d EM morphologies overlaid on 5HT7-GAL4 expression pattern. Individual neuron: ER4d (1198693217).