Table 2.
Ingredients of GQD used in the 11 RCTs.
| RCT | TCM | The way of taking medicine | Course of treatment (day) | Ingredients | Adverse event |
|---|---|---|---|---|---|
| Sha et al. [22] | Modified GQD (1 dose/d) | Oral | 3 | Puerariae lobatae radix (Ge Gen) 10 g, scutellariae radix (Huang Qin) 6 g, Coptidis rhizoma (Huang Lian) 3 g, Glycyrrhizae radix (Gan Cao) 3 g, Atractylodis rhizoma (Cang Zhu) 6 g, Pogostemonis herba (Huo Xiang) 6 g, magnoliae officinalis cortex (Hou Po) 6 g, citri reticulatae pericarpium (Chen Pi) 6 g, poria (Fu Ling) 10 g, and mume fructus (Wu Mei) 3 g | NM |
|
| |||||
| Xu et al. [21] | Modified GQD (2 ml/kg, tid-qid) | Oral | 5 | Puerariae lobatae radix (Ge Gen), Scutellariae radix (Huang Qin), Coptidis rhizoma (Huang Lian), Glycyrrhizae radix (Gan Cao), atractylodis rhizoma (Cang Zhu), poria (Fu Ling), hordei fructus germinatus (Mai Ya), setariae fructus germinatus (Gu Ya), raphani semen (Lai Fuzi), Atractylodis macrocephalae rhizoma (Bai Zhu), and galli gigerii endothelium corneum (Ji Neijin) | NM |
|
| |||||
| Liu [35] | Modified GQD (1 dose/d) | Oral | — | Puerariae lobatae radix (Ge Gen) 5 g, Scutellariae radix (Huang Qin) 4 g, Coptidis rhizoma (Huang Lian) 3 g, pogostemonis herba (Huo Xiang) 6 g, Atractylodis macrocephalae rhizoma (Bai Zhu) 6 g, amomi fructus rotundus (Bai Doukou) 3 g, Isatudis radix (Ban Langen) 12 g, indigo naturalis (Qing Dai) 3 g, papaveris pericarpium (Ying Suke) 2 g, Aucklandiae radix (Mu Xiang) 3 g, mume fructus (Wu Mei) 12 g, and poria (Fu Ling) 10 g | NM |
|
| |||||
| Ma et al. [33] | Modified GQD (2 ml/kg, bid) | Oral | 7 | Puerariae lobatae radix (Ge Gen) 8 g, Scutellariae radix (Huang Qin) 6 g, Coptidis rhizoma (Huang Lian) 5 g, Glycyrrhizae radix (Gan Cao) 3 g, Alismatis rhizoma (Ze Xie) 6 g, Aucklandiae radix (Mu Xiang) 8 g, and poria (Fu Ling) 8 g | NM |
|
| |||||
| Shi et al. [32] | GQD (1 dose/d) | Oral | 3–6 | Puerariae lobatae radix (Ge Gen) 9 g, Scutellariae radix (Huang Qin) 6 g, Coptidis rhizoma (Huang Lian) 6 g, and Glycyrrhizae radix (Gan Cao) 3 g | M |
|
| |||||
| Lu et al. [34] | Modified GQD (1 dose/d) | Oral | 3 | Puerariae lobatae radix (Ge Gen) 10 g, Scutellariae radix (Huang Qin) 6 g, Coptidis rhizoma (Huang Lian) 3 g, Gglycyrrhizae radix (Gan Cao) 3 g, poria (Fu Ling)10 g, Atractylodis rhizoma (Cang Zhu) 6 g, pogostemonis herba (Huo Xiang) 6 g, magnoliae officinalis cortex (Hou Po) 6 g, citri reticulatae pericarpium (Chen Pi) 6 g, and mume fructus (Wu Mei) 3 g | NAE |
|
| |||||
| Zhang and Li [31] | Modified GQD (1 dose/d) | Oral | 3 | Puerariae lobatae radix (Ge Gen) 10 g, Scutellariae radix (Huang Qin) 6 g, Coptidis rhizoma (Huang Lian) 3 g, Glycyrrhizae radix (Gan Cao) 3 g, poria (Fu Ling) 10 g, pogostemonis herba (Huo Xiang) 6 g, magnoliae officinalis cortex (Hou Po) 6 g, mume Fructus (Wu Mei) 3 g, Atractylodis rhizoma (Cang Zhu) 6 g, and citri reticulatae pericarpium (Chen Pi) 6 g | NAE |
|
| |||||
| Huang et al. [38] | GQD (1 dose/d) | Oral | 3–7 | Puerariae lobatae radix (Ge Gen) 9 g, Scutellariae radix (Huang Qin) 6 g, Coptidis rhizoma (Huang Lian) 6 g, and Glycyrrhizae radix (Gan Cao) 3 g | NM |
|
| |||||
| Huang and Dong [37] | GQD (1 dose/d) | Oral | 7 | Puerariae lobatae radix (Ge Gen) 15 g, sScutellariae radix (Huang Qin) 9 g, Coptidis rhizoma (Huang Lian) 3 g, and Glycyrrhizae radix (Gan Cao) 5 g | M |
|
| |||||
| Fang and Hang [39] | Modified GQD (1 dose/d) | Oral | 3 | Puerariae lobatae radix (Ge Gen) 15 g, Scutellariae radix (Huang Qin) 10 g, Coptidis rhizoma (Huang Lian) 6 g, Glycyrrhizae radix (Gan Cao) 6 g, plantaginis semen (Che Qianzi) 12 g, massa medicata fermentata (Shen Qu) 10 g, and Aucklandiae radix (Mu Xiang) 6 g | NAE |
|
| |||||
| Li and Jiang [36] | Modified GQD (1 dose/d) | Oral | — | Puerariae lobatae radix (Ge Gen) 10 g, Scutellariae radix (Huang Qin) 5 g, Coptidis rhizoma (Huang Lian) 5 g, Glycyrrhizae radix (Gan Cao) 5 g, and Atractylodis macrocephalae rhizoma (Bai Zhu) 10 g | NAE |
Abbreviations: “—” = not explicitly mentioned in the trials; NM = not mentioned; M = mentioned; NAE = no adverse events.