Table 4:
Overall and complete response rate with trends by cancer type during 2000 to 2019
| Year | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2000–2005 | 2006–2012 | 2013–2019 | |||||||||
| Number of patients | % | 95%CI | % | 95%CI | % | 95%CI | % | 95%CI | p-value | ||
| Overall response | All patients | 9325 | 12.2 | (11.5, 12.8) | 9.6 | (8.7, 10.6) | 13.1 | (12.1, 14.2) | 18.0 | (15.7, 20.5) | <0.001 |
| Bladder | 186 | 22.0 | (16.3, 28.7) | 8.5 | (2.4, 20.4) | 22.5 | (10.8, 38.5) | 28.3 | (19.7, 38.2) | 0.006 | |
| Breast | 855 | 15.8 | (13.4, 18.4) | 7.9 | (4.6, 12.5) | 18.4 | (15.4, 21.8) | 16.4 | (7.8, 28.8) | 0.003 | |
| Colon | 1092 | 5.4 | (4.1, 6.9) | 7.7 | (5.7, 10.2) | 2.4 | (1.1, 4.3) | 4.7 | (1.3, 11.5) | 0.002 | |
| Kidney | 276 | 11.6 | (8.1, 16.0) | 3.4 | (1.1, 7.7) | 19.3 | (11.4, 29.4) | 25.0 | (13.2, 40.3) | <0.001 | |
| Lung | 632 | 21.2 | (18.1, 24.6) | 21.3 | (17.1, 26.0) | 14.3 | (9.1, 21.0) | 28.2 | (21.0, 36.3) | 0.255 | |
| Melanoma | 474 | 7.8 | (5.6, 10.6) | 6.7 | (4.2, 10.1) | 4.2 | (1.4, 9.6) | 25.6 | (13.5, 41.2) | 0.006 | |
| Ovary | 656 | 30.5 | (27.0, 34.2) | 14.6 | (9.0, 21.9) | 36.4 | (32.1, 41.0) | 16.7 | (7.9, 29.3) | 0.03 | |
| Pancreas | 375 | 2.9 | (1.5, 5.2) | 1.8 | (0.4, 5.3) | 5.1 | (2.1, 10.2) | 1.4 | (0.0, 7.4) | 0.788 | |
| Prostate | 212 | 6.1 | (3.3, 10.3) | 3.3 | (1.1, 7.5) | 14.6 | (6.5, 26.67 | 0.0 | (0, 60.2) | 0.03 | |
| Others | 4567 | 10.3 | (9.5, 11.2) | 10.1 | (8.8, 11.5) | 9.2 | (8.0, 10.5) | 16.9 | (13.5, 20.7) | 0.012 | |
| Complete response | All patients | 9325 | 2.7 | (2.4, 3.0) | 2.5 | (2.0, 3.0) | 2.4 | (2.0, 3.0) | 4.3 | (3.2, 5.7) | 0.018 |
| Bladder | 186 | 4.8 | (2.2, 9.0) | 0.0 | (0, 7.6) | 0.0 | (0, 8.8) | 9.1 | (4.2, 16.6) | 0.001 | |
| Breast | 855 | 2.6 | (1.6, 3.9) | 0.0 | (0, 1.8) | 3.2 | (19, 4.9) | 5.5 | (1.1, 15.1) | 0.004 | |
| Colon | 1092 | 0.5 | (0.2, 1.1) | 0.9 | (0.3, 2.0) | 0.0 | (0, 0.9) | 0.0 | (0, 4.2) | 0.012 | |
| Kidney | 276 | 0.7 | (0.1, 2.6) | 0.0 | (0, 2.5) | 0.0 | (0, 4.4) | 4.6 | (0.6, 15.5) | 0.006 | |
| Lung | 632 | 1.6 | (0.8, 2.9) | 1.8 | (0.6, 3.8) | 0.7 | (0, 3.7) | 2.1 | (0.4, 6.1) | 0.944 | |
| Melanoma | 474 | 1.5 | (0.6, 3.0) | 1.3 | (0.4, 3.2) | 0.0 | (0, 3.1) | 7.0 | (1.5, 19.1) | 0.112 | |
| Ovary | 656 | 9.3 | (7.2, 11.8) | 4.6 | (1.7, 9.8) | 11.4 | (8.7, 14.7) | 1.9 | (0.1, 9.9) | 0.590 | |
| Pancreas | 375 | 0.0 | (0, 1.0) | 0.0 | (0, 2.2) | 0.0 | (0, 2.6) | 0.0 | (0, 4.9) | 1.000 | |
| Prostate | 212 | 0.0 | (0, 1.7) | 0.0 | (0, 2.4) | 0.0 | (0, 6.5) | 0.0 | (0, 60.2) | 1.000 | |
| Others | 4567 | 2.9 | (2.4, 3.4) | 4.1 | (3.2, 5.1) | 1.4 | (0.9, 2.0) | 5.4 | (3.5, 7.9) | 0.114 | |
Abbreviations: CI, confidence interval computed using the exact method; p-values are derived from the likelihood ratio test using the logistic regression model