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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Eur J Pharm Sci. 2022 Jul 29;177:106272. doi: 10.1016/j.ejps.2022.106272

Table 1.

Regularized dichotomous model of acinar airways from the transitional bronchiole (generation z’= 0) and terminal alveolar sacs (generation z’=8) (Weibel et al., 2005).

z’ N L (mm) D (mm) Salv (mm2) qa qdi qde v¯d
0 1 1.40 0.50 7 1.30E-03 1.00E+00 9.99E-01 9.99E-01
1 2 1.33 0.50 23 4.28E-03 4.99E-01 4.97E-01 4.98E-01
2 4 1.12 0.49 67 1.25E-02 2.49E-01 2.45E-01 2.47E-01
3 8 0.93 0.40 129 2.40E-02 1.23E-01 1.20E-01 1.21E-01
4 16 0.83 0.38 219 4.07E-02 5.99E-02 5.73E-02 5.86E-02
5 32 0.70 0.36 349 6.49E-02 2.87E-02 2.66E-02 2.77E-02
6 64 0.70 0.34 661 1.23E-01 1.33E-02 1.17E-02 1.25E-02
7 125 0.70 0.31 1204 2.24E-01 5.84E-03 3.95E-03 4.89E-03
8 256 0.70 0.29 2720 5.06E-01 1.98E-03 2.22E-16 9.88E-04

z’, generation number in acinar airways; N, number of branches; L, mean length of segments; D, mean inner diameter of segments; Salv, total alveolar surface per generation (the sum of Salv over all z’ is Salv=5379mm2 ); qa(z’), normalized flow rate into all alveolar sacs per generation calculated by Salvv¯alv where v¯alv=1/Salv and zSalvv¯alv=1; qdi(z \prime ), normalized flow rate at the inlet of an airway segment calculated by [qdi(z1)qa(z1)]/N(z);qde(z), normalized flow rate at the exit of an airway segment equaling 2·qdi(z+1); the mean normalized flow rate inside an airway segment q¯d is (qdi+qde)/2. qa, qdi and qde are normalized flow rates by the flow rate at the transitional bronchiole Qdi(z=0).