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. 2022 Jun 29;609(7927):605–610. doi: 10.1038/s41586-022-04883-y

Fig. 3. Conformational change and the support site.

Fig. 3

a, Inward and outward structures superposed on the scaffold domain (blue) reveal an elevator-type movement, with the substrate binding site moving 5 Å. b, Close-up view of the NPA map density and the residues interacting with it. c, The hydrogen-bonding network linking the binding site to the support site through Gln145 in the outward state (top) and inward state (bottom).