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. 2022 Jun 29;609(7927):605–610. doi: 10.1038/s41586-022-04883-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Workflow of image processing and 3D reconstruction in cryoSPARC, including a motion corrected micrograph from Titan Krios microscope using a K3 detector, 2D classes and sharpened density map from the final non-linear refinement colored by local resolution. Corrected curve of the global FSC indicates 3.18 Å based on the 0.143 gold-standard criterion. The cryo-EM experiment with this sample was repeated 6 times with data collection 1 time.