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. 2022 Aug 2;609(7927):611–615. doi: 10.1038/s41586-022-05143-9

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© The Author(s) 2022

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Fig. 2 — a, An overview of the crossover structure of TM4 (cyan) and TM9 (orange). b, The crossover structure of TM4 and TM9 is stabilized by the positively charged R547 in TM8. Positions corresponding to the two sodium binding sites in ASBT_NM are indicated by dashed outlines. Magnified views are shown for each site. c, PIN1 contains a cytosolic domain (cyan) composed of three β-strands. Ionic interactions between the transmembrane segments and the β1–β2 linker are shown as red dashed lines.