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. 2022 Aug 23;23(9):1317–1323. doi: 10.1038/s41590-022-01284-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a–c, Multiphoton microscopy of the small intestine of mixed bone marrow chimeras generated by injection of whole bone marrow CD45.2⁺ cells from Actb^CFP and Rag2^−/−Rorc^GFPIl22^TdT mice into lethally irradiated congenic CD45.1⁺ C57BL/6J mice 7 weeks post-transfer. a, Representative image (left; scale bar, 50 µm) and time-lapse images (right; scale bar, 15 µm) of ILC3s and CFP⁺ cells in intestinal villi or ILF of bone marrow chimera. b, Individual tracks of intestinal Actb^ECFP+ cells and Rorc^GFP+ ILC3s in intestinal villi or ILF. c, Mean speed, arrest coefficient and straightness ratio of indicated populations in the intestine. Results in b,c are from two (Actb^ECFP+ cells and Rorc^GFP+ ILC3s in ILFs) or nine movies (Rorc^GFP+ ILC3s in intestinal villi) obtained in two independent experiments (n = 170 Actb^ECFP+ cells; n = 49 Rorc^GFP+ ILC3ss (intestinal villi); n = 38 Rorc^GFP+ ILC3s (ILFs)). Each line corresponds to the mean ± s.e.m. of the values obtained; only ILC3s were tested (**P < 0.002; ***P < 0.001; two-tailed Mann–Whitney U-test; exact P values are provided in the source data).

Source data