Extended Data Fig. 12. Trypsin degradation by 00502-carrying species.
a, Degradation of recombinant mouse trypsin (rmPRSS2) following in vitro incubation with the indicated bacterial strains. b, Quantification of faecal DNA from Prevotella rodentium and Prevotella muris in SPF mice reared at RIKEN’s facility by RT-qPCR. c, Alexa Fluor 488-labelled rmPRSS2 (green) was incubated with the indicated strains, and association of rmPRSS2 with the bacterial surface was examined by confocal microscopy. Scale bar: 5 μm (c). b, Data shown as geometric mean ± geometric s.d. n = 5 mice. DL, detection limit. N. D., not detected. a, c, A representative image from two independent experiments with similar results (a), or images from one experiment (c) are shown. See Supplementary Figure 1 for blot source data.