Extended Data Fig. 1. Elevated trypsin levels in germ free (GF) mice, and in humans and mice with intestinal inflammation.
Distribution of all host-derived proteins detected in the proteome analysis of the caecal contents from specific-pathogen-free (SPF) or GF mice, with protein relative abundance plotted against p value. Anionic trypsin 2 (PRSS2) is highlighted in red. See Supplementary Table 1 for the complete list of proteins detected. b, Faecal trypsin activity of healthy controls, ulcerative colitis (UC) and Crohn’s disease (CD) patients. c, Faecal trypsin activity of Il10+/− and Il10−/− mice. b, c, Data shown as mean ± s.d. Each dot represents one human subject or one mouse. ** p < 0.01; * p < 0.05. One-way ANOVA with Tukey’s test (b) and two-sided Mann-Whitney test with Welch’s correction (nonparametric) (c).